Causal relationship between obesity and vitamin D status: Bi-directional mendelian randomization analysis of multiple cohorts

Causal relationship between obesity and vitamin D status: Bi-directional mendelian randomization analysis of multiple cohorts

Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. The study explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis.

On the basis of a bi-directional genetic approach that limits confounding, this paper suggests that a higher BMI leads to lower 25(OH)D, while any effects of lower 25(OH)D increasing BMI are likely to be small. Population level interventions to reduce BMI are expected to decrease the prevalence of vitamin D deficiency.