GDNet builds the capacity of researchers from developing and transition countries to inform global development research and policy. In its early years, GDNet focused on information and knowledge management staff in developing country research institutes and piloted a series of knowledge management workshops in Africa. In 2007 a conference in Cairo, in partnership with the ACBF and the World Bank Institute, brought together the experiences and lessons learned from efforts to build knowledge management capacity from across the African continent. Two key themes emerged: 1. the need to create an enabling environment for the adoption of knowledge management practices 2. the importance of indigenous knowledge assets as inputs to poverty alleviation strategies. This paper revisits these discussions to question progress made towards meeting these challenges and share how GDNet’s capacity building activities have evolved in the light of the conference findings.