Limitations of ARVs

Questions persist about the feasibility of providing ARV treatment to large numbers of people in resource-limited settings. Concerns raised often include:

• the negative impact that the severe side-effects of HIV drugs and the complexity of treatment have on the ability of people to adhere to their ART regime;
• the unknown long-term impact of the drug toxins;
• the complex nutritional impact on, and needs, of people on ART
• the scarcity of necessary trained health care providers;
• and insufficent infrastructure to monitor patients
  

All these concerns call into question the long-term sustainability of ART and without sustainability the most dangerous challange of drug resistance becomes a major threat.