A Family of Juvenile Idiopathic Arthritis: Case Report

A Family of Juvenile Idiopathic Arthritis: Case Report

Published Jan 2010

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Juvenile idiopathic arthritis (JIA) is arthritis of unknown etiology that begins before the 16th birthday and persists for at least 6 weeks; other known conditions are excluded1. JIA is a complex genetic trait. Despite the genetic contributions to disease risk observed in many case-controls studies, familial JIA is rare2. The level of risk to family members of a JIA proband appears to be relatively low as compared with other autoimmune diseases3-5. Because no one gene or mutation is sufficient to result in disease, but must interact with one or more other genetic factors, the probability of disease occurring in more than one family member is relatively low.

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